The Friday MLB schedule is loaded with 15 games and all 30 MLB teams playing on the inaugural Rivalry Weekend slate. One of the most notable matchups of the day is Yankees vs. Mets in Game 1 of the latest edition of the Subway Series. First pitch from Yankee Stadium in the Bronx is scheduled for 7:05 p.m. ET. This will be the first game for Juan Soto in Yankee Stadium since signing with the Mets during the offseason. Tylor MeGill 3-3, 3.10 ERA is slated to start for the Mets, while Carlos Rodon 4-3, 3.29 ERA is scheduled to be on the mound for the Yankees.
The Yankees are -148 favorites risk $148 to win $100 on the money line, while the over under is 9 runs in the latest MLB odds for Thursday. Should you back the Yankees or Mets when making MLB picks on Friday? Before making any MLB picks or building any MLB parlay cards, youll want to see the MLB predictions and betting advice from SportsLines proven computer simulation model.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 8 of the 2025 MLB season on a 12-8 run 60% on top-rated MLB money-line betting picks. The model cashed its MLB parlay on Wednesday for a massive 9-1 payout. Anybody following at sportsbooks and on betting apps could have seen strong returns.
The model has broken down the MLB odds for Friday and just revealed its top picks and MLB player props. Combining the models three picks into an MLB parlay at DraftKings Sportsbook would result in a payout of +756 risk $100 to win $756. Now, here are its best bets for the MLB slate on Friday:
Rockies-Diamondbacks over 9 runs -111
The Rockies are on pace to have a historically bad season, and enter with a 7-36 overall record. The Diamondbacks are 23-21 overall and have been one of the top offensive teams in MLB. LHP Carson Palmquist is expected to make his MLB debut at the starting pitcher for the Rockies. The model is projecting 11.1 total runs in this game, with the over hitting in 63.5% of computer simulations.
Aaron Judge to hit 1+ home runs vs. New York Mets +186
Judge is a threat to leave the yard every time he steps into the batters box — especially in games at Yankee Stadium. He hit his MLB-leading 15th home run of the season in the Yankees 3-2 win over the Seattle Mariners on Wednesday. SportsLines model is projecting Ohtani to finish with another strong stat line — 1.25 hits and 2.35 total bases against the Mets on Friday.
Seattle Mariners +1.5 on the run line vs. San Diego Padres -152
Both teams have played well in 2025 — Seattle is 23-19 overall, while San Diego is 27-15 overall. Logan Evans 1-1, 6.60 ERA is slated to start for the Mariners, and Stephen Kolek 2-0, 0.00 ERA is expected to start for the Padres. SportsLines model is projecting a final score of 4.8-4.7 in San Diegos favor, with the Mariners covering in 70% of computer simulations.
Combine these picks for a shot at a +756 payout. Bet it now at DraftKings and get $200 in Bonus Bets instantly when you wager $5.
Want more MLB picks for today?
Youve seen some of the models MLB best bets for Friday. Now, get run line, total and money-line picks for every game here, all from the model thats simulated every game 10,000 times.
Also at SportsLine:
You can also see todays top MLB picks from expert Matt Severance, whos on a sizzling 110-52 roll on his last 161 MLB picks. Visit SportsLine to see his best plays for today, all from the expert whos up more than 22 units. ,
